The miRNA binding site SNP in the 3′ UTR of NBS1 is inversely associated with breast cancer risk
نویسندگان
چکیده
منابع مشابه
rs2735383, located at a microRNA binding site in the 3’UTR of NBS1, is not associated with breast cancer risk
NBS1, also known as NBN, plays an important role in maintaining genomic stability. Interestingly, rs2735383 G > C, located in a microRNA binding site in the 3'-untranslated region (UTR) of NBS1, was shown to be associated with increased susceptibility to lung and colorectal cancer. However, the relation between rs2735383 and susceptibility to breast cancer is not yet clear. Therefore, we genoty...
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BACKGROUND Single nucleotide polymorphisms (SNPs) that reside in microRNA target sites may play an important role in breast cancer development and progression. To reveal the association between microRNA target site SNPs and breast cancer risk, we performed a large case-control study in China. METHODS We performed a two-stage case-control study including 2744 breast cancer cases and 3125 contr...
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BACKGROUND Research into the etiology of breast cancer has recently focused on the role of the immunity and inflammation. Interleukin-23 and its receptor (IL23R) guide T cells towards the Th17 phenotype. IL23R single nucleotide polymorphisms (SNPs) have been shown to be associated with digestive system cancers. To evaluate the influences of IL23R gene polymorphisms on the risk of sporadic breas...
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ژورنال
عنوان ژورنال: Journal of Cellular Immunotherapy
سال: 2018
ISSN: 2352-1775
DOI: 10.1016/j.jocit.2018.09.013